Neonatal neurobehavior effects following buprenorphine versus methadone exposure
نویسندگان
چکیده
منابع مشابه
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However, prenatal exposure to methadone is associated with a neonatal abstinence syndrome (NAS) characterized by central nervous system hyperirritability and autonomic nervous system dysfunction, which often requires medication and extended hospitalization. Buprenorphine, a parti...
متن کاملNeonatal outcomes following in utero exposure to buprenorphine/naloxone or methadone
OBJECTIVES To study neonatal outcomes following buprenorphine/naloxone and methadone exposure during pregnancy. METHODS This study is a retrospective review of clinical and demographic information of 58 infants whose mothers were treated with buprenorphine/naloxone and 92 infants whose mothers were treated with methadone for opioid dependence during pregnancy. RESULTS Gestational age, birth...
متن کاملSystematic Reviews and Meta- and Pooled Analyses Prenatal Buprenorphine Versus Methadone Exposure and Neonatal Outcomes: Systematic Review and Meta-Analysis
Increasing rates of maternal opioid use during pregnancy and neonatal withdrawal, termed neonatal abstinence syndrome (NAS), are public health concerns. Prenatal buprenorphinemaintenance treatment (BMT) versusmethadone maintenance treatment (MMT) may improve neonatal outcomes, but associations vary. To summarize evidence, we used a random-effects meta-analysis model and estimated summary measur...
متن کاملBuprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome.
This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial. This randomized, double-blind, double-dummy, flexible dosing, parallel-group controlled trial was conducted in a comprehensive drug-treatment facility t...
متن کامل'Diversion’ of methadone or buprenorphine: 'harm’ versus 'helping’
BACKGROUND 'Non-compliant' individuals in opioid maintenance treatment, OMT, are often met with tight control regimes to reduce the risk of 'diversion', which may lead to harm or death among persons outside of OMT. This article explores reported practices of, and motivations for, diversion of methadone and buprenorphine, in a group of imprisoned individuals in OMT. FINDINGS 28 in-depths inter...
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ژورنال
عنوان ژورنال: Addiction
سال: 2012
ISSN: 0965-2140
DOI: 10.1111/j.1360-0443.2012.04040.x